… By examining the impact of lifespan on pathogen spread in a population, we propose that
epidemics drive lifespan setpoints’ evolution. Shorter lifespan limits infection spread and …

… coevolution played a key role in determining the lifespan setpoints of a species. A population
of … Finally, considering lifespan termination as an adaptive trait, our theory does not provide …

… in host health – so as to promote the life span of the hosts in the absence of the disease – …
, setting off an outbreak of an earlier, competitively inferior strain. An unexpected finding is that …

… traits but not a programmed adaptive process. Alternatively, … for the evolution of lifespan
set points, and a consensus on the … infectious diseases could shape the evolution of lifespan. …

… adaptive mechanisms generated by immunosenescence and inflammaging determine the
susceptibility to several diseases… the major age-associated diseases. They indeed show a …

… /IGF-1 could more than double the lifespan (LS) of the nematode … The moving force of evolution
is natural selection of random … We believe that infection outbreaks can promote control of …

… of life span, chronic degenerative diseases, and adaptability. … across a wide variety of
environmental and cultural settings. … evolutionary history necessarily determine to some degree …

… for the evolution of complex organisms that demand adaptive … is a major driving force in
determining the differential … operate throughout the life span and determine the rate of aging, …

… a lifetime of chronic or excessively repetitive adaptive stimuli, … A major driving force in the
activation of the transient stress … approaches to several diseases. Indeed, multiple chronic …

… signaling pathways that promote an adaptive response [11, … complex role in determining
longevity than previously thought… ] has been implicated as the driving force in the aging process, …